Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.11/5735
Title: Chemical composition of laurencia obtusa extract and isolation of a new C15-acetogenin
Author: Esselin, Hélène
Sutour, Sylvain
Liberal, Joana
Cruz, Maria Teresa
Salgueiro, Ligia
Siegler, Benjamin
Freuze, Ingrid
Castola, Vincent
Paoli, Mathieu
Bighelli, Ange
Tomi, Félix
Keywords: Laurencia obtusa
13C-NMR
Corsica
Cytotoxic activity
Sagonenyne
Issue Date: May-2017
Publisher: MDPI AG
Citation: ESSELIN, Hélène [et al.] (2017) - Chemical composition of laurencia obtusa extract and isolation of a new C15-acetogenin. Molecules. ISSN 1420-3049. Vol. 22, nº 5, p. 779-790
Abstract: A new C15-acetogenin, sagonenyne (20), exhibiting an unusual single tetrahydropyran ring was isolated from an ethyl acetate extract of Laurencia obtusa collected on the Corsican coastline. Its structure was established by detailed NMR spectroscopic analysis, mass spectrometry, and comparison with literature data. Twenty-three known compounds were identified in the same extract by means of column chromatography steps, using a (13)C-NMR computer aided method developed in our laboratory. In addition to sesquiterpenes, which represent the main chemical class of this extract, diterpenes, sterols, and C15-acetogenins were identified. The crude extract was submitted to a cytotoxicity assay and was particularly active against THP-1 cells, a human leukemia monocytic cell line.
Peer review: yes
URI: http://hdl.handle.net/10400.11/5735
DOI: 10.3390/molecules22050779
ISSN: 1420-3049
Publisher Version: http://www.mdpi.com/1420-3049/22/5/779
Appears in Collections:ESALD - Artigos em revistas com arbitragem científica

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