Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.11/5735
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dc.contributor.authorEsselin, Hélène-
dc.contributor.authorSutour, Sylvain-
dc.contributor.authorLiberal, Joana-
dc.contributor.authorCruz, Maria Teresa-
dc.contributor.authorSalgueiro, Ligia-
dc.contributor.authorSiegler, Benjamin-
dc.contributor.authorFreuze, Ingrid-
dc.contributor.authorCastola, Vincent-
dc.contributor.authorPaoli, Mathieu-
dc.contributor.authorBighelli, Ange-
dc.contributor.authorTomi, Félix-
dc.date.accessioned2017-11-06T14:39:49Z-
dc.date.available2017-11-06T14:39:49Z-
dc.date.issued2017-05-
dc.identifier.citationESSELIN, Hélène [et al.] (2017) - Chemical composition of laurencia obtusa extract and isolation of a new C15-acetogenin. Molecules. ISSN 1420-3049. Vol. 22, nº 5, p. 779-790pt_PT
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/10400.11/5735-
dc.description.abstractA new C15-acetogenin, sagonenyne (20), exhibiting an unusual single tetrahydropyran ring was isolated from an ethyl acetate extract of Laurencia obtusa collected on the Corsican coastline. Its structure was established by detailed NMR spectroscopic analysis, mass spectrometry, and comparison with literature data. Twenty-three known compounds were identified in the same extract by means of column chromatography steps, using a (13)C-NMR computer aided method developed in our laboratory. In addition to sesquiterpenes, which represent the main chemical class of this extract, diterpenes, sterols, and C15-acetogenins were identified. The crude extract was submitted to a cytotoxicity assay and was particularly active against THP-1 cells, a human leukemia monocytic cell line.pt_PT
dc.language.isoengpt_PT
dc.publisherMDPI AGpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLaurencia obtusapt_PT
dc.subject13C-NMRpt_PT
dc.subjectCorsicapt_PT
dc.subjectCytotoxic activitypt_PT
dc.subjectSagonenynept_PT
dc.titleChemical composition of laurencia obtusa extract and isolation of a new C15-acetogeninpt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage779pt_PT
degois.publication.titleMoleculespt_PT
dc.relation.publisherversionhttp://www.mdpi.com/1420-3049/22/5/779pt_PT
dc.peerreviewedyespt_PT
degois.publication.volume22pt_PT
dc.identifier.doi10.3390/molecules22050779pt_PT
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