Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.11/5737
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dc.contributor.authorLiberal, Joana-
dc.contributor.authorCarmo, Anália-
dc.contributor.authorGomes, Célia-
dc.contributor.authorCruz, Maria Teresa-
dc.contributor.authorBatista, Maria Teresa-
dc.date.accessioned2017-11-07T15:50:17Z-
dc.date.available2017-11-07T15:50:17Z-
dc.date.issued2017-07-20-
dc.identifier.citationLiberal, J., Carmo, A., Gomes, C. et al. Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells. Invest New Drugs (2017). https://doi.org/10.1007/s10637-017-0483-7pt_PT
dc.identifier.issn0167-6997-
dc.identifier.urihttp://hdl.handle.net/10400.11/5737-
dc.description.abstractEllagitannins have been gaining attention as potential anticancer molecules. However, the low bioavailability of ellagitannins and their extensive metabolization in the gastrointestinal tract into ellagic acid and urolithins suggest that the health benefits of consuming ellagitannins rely on the direct effects of their metabolites. Recently, chemopreventive and chemotherapeutic activities were ascribed to urolithins. Nonetheless, there is still a need to screen and evaluate the selectivity of these molecules and to elucidate their cellular mechanisms of action. Therefore, this work focused on the antiproliferative effects of urolithins A, B and C and ellagic acid on different human tumor cell lines. The evaluation of cell viability and the determination of the half-maximal inhibitory concentrations indicated that the sensitivity to the studied urolithins varied markedly between the different cell lines, with the bladder cancer cells (UMUC3) being the most susceptible. In UMUC3 cells, urolithin A was the most active molecule, promoting cell cycle arrest at the G2/M checkpoint, increasing apoptotic cell death and inhibiting PI3K/Akt and MAPK signaling. Overall, the present study emphasizes the chemopreventive/chemotherapeutic potential of urolithins, highlighting the stronger effects of urolithin A and its potential to target transitional bladder cancer cells.pt_PT
dc.language.isoengpt_PT
dc.publisherSpringer USpt_PT
dc.relationCENTRO-01-0145-FEDER-000012-HealthyAging2020pt_PT
dc.relationCOMPETE 2020 Operational Programme for Competitiveness and Internationalisationpt_PT
dc.relationPOCI-01-0145-FEDER-007440pt_PT
dc.relationPh.D. fellowship SFRH/BD/72918/2010pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectApoptosispt_PT
dc.subjectCell cyclept_PT
dc.subjectEllagitanninspt_PT
dc.subjectIntracellular signaling pathwayspt_PT
dc.subjectUMUC3pt_PT
dc.subjectUrolithinspt_PT
dc.titleUrolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cellspt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.titleInvestigational New Drugspt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10637-017-0483-7pt_PT
dc.peerreviewedyespt_PT
dc.identifier.doi10.1007/s10637-017-0483-7pt_PT
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