Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.11/5736
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dc.contributor.authorSantos, Telmo N.-
dc.contributor.authorCosta, Gustavo-
dc.contributor.authorFerreira, J. Pinto-
dc.contributor.authorLiberal, Joana-
dc.contributor.authorFrancisco, Vera-
dc.contributor.authorParanhos, António-
dc.contributor.authorCruz, Maria T.-
dc.contributor.authorCastelo-Branco, M.-
dc.contributor.authorFigueiredo, I. Vitória-
dc.contributor.authorBatista, M. Teresa-
dc.identifier.citationSANTOS, Telmo N. [et al.] - Antioxidant, anti-inflammatory, and analgesic activities of agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine. ISSN. 1741-427X. (2017) p. 1-13pt_PT
dc.description.abstractAgrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MS (n) . To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively. Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.pt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relationFEDER/COMPETE (FCOMP-01-0124-FEDER-011096)pt_PT
dc.relationFCT Project PTDC/SAU-FCF/105429/2008pt_PT
dc.relationFCT Project PEst-OE/SAU/UI0177/2011pt_PT
dc.subjectAgrimonia eupatoria L.pt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectAnalgesic activitypt_PT
dc.titleAntioxidant, anti-inflammatory, and analgesic activities of agrimonia eupatoria L. Infusionpt_PT
degois.publication.titleEvidence-Based Complementary and Alternative Medicinept_PT
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