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Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infection

2024-06-02Research article Open access
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dc.contributor.authorLindo, Jorge
dc.contributor.authorNogueira, Célia
dc.contributor.authorSoares, Rui
dc.contributor.authorCunha, Nuno
dc.contributor.authorAlmeida, Maria Rosário
dc.contributor.authorRodrigues, Lisa
dc.contributor.authorCoelho, Patricia
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorGonçalves, Teresa
dc.date.accessioned2025-09-17T15:19:33Z
dc.date.available2025-09-17T15:19:33Z
dc.date.issued2024-06-02en_US
dc.date.updated2025-09-16T09:08:57Z
dc.descriptionThe authors acknowledge the support of the board of directors of IPSS - Casa do Pai and the technical support of NP Tânia Oliveira.
dc.description.abstractSARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic andgenotypic frequencies of a loss-of-function SNP of ADORA2A (rs2298383) and a gain-of-function single nucleotide polymorphism (SNP) of P2RX7 (rs208294) in the severity of SARS-CoV-2-associated infection. Fifty-five individuals were enrolled and categorized according to the severity of the infection. Endpoint genotyping was performed in blood cells to screen for both SNPs. The TT genotype (vs. CT + CC) and the T allele (vs. C allele) of P2RX7 SNP were found to be associated with more severe forms of COVID-19, whereas the association between ADORA2A SNP and the severity of infection was not significantly different. The T allele of P2RX7 SNP was more frequent in people with more than one comorbidity and with cardiovascular conditions and was associated with colorectal cancer. Our findings suggest a more prominent role of P2X7R rather than of A2AR polymorphisms in SARS-CoV-2 infection, although larger population-based studies should be performed to validate our conclusions.eng
dc.description.sponsorshipThis research was funded by La Caixa Foundation (HP17/00523), Centro 2020 (CENTRO-01-0145-FEDER-000008:BrainHealth2020 and CENTRO-01-0246-FEDER-000010) and FCT (UIDB/04539/2020, UIDP/04539/2020 and LA/P/0058/2020).
dc.description.versionN/A
dc.identifier.citationLINDO, J. [et al.] (2024) - Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infection. Int. J. Mol. Sci. N.º 25, 6135. DOI: 10.3390/ijms25116135
dc.identifier.doi10.3390/ijms25116135en_US
dc.identifier.slugcv-prod-4154060
dc.identifier.urihttp://hdl.handle.net/10400.11/10295
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationSAICTCOVID/72546/2020en_US
dc.relation10.54499/SAICTCOVID/72546/2020en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdenosine A2A receptor
dc.subjectATP P2X7 receptor
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectPolymorphisms
dc.titleGenetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infectioneng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Molecular Sciencesen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoelho
person.familyNameRodrigues
person.givenNamePatricia
person.givenNameFrancisco
person.identifier2982790
person.identifier.ciencia-id231C-F92A-1BC2
person.identifier.ciencia-id7A18-045E-330C
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublication30f36b8c-0bee-46cd-9ecf-be2a8dc33bd6
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication.latestForDiscovery30f36b8c-0bee-46cd-9ecf-be2a8dc33bd6

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