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Antioxidant, anti-inflammatory, and analgesic activities of agrimonia eupatoria L. Infusion

2017Journal article Open access
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dc.contributor.authorSantos, Telmo N.
dc.contributor.authorCosta, Gustavo
dc.contributor.authorFerreira, J. Pinto
dc.contributor.authorLiberal, Joana
dc.contributor.authorFrancisco, Vera
dc.contributor.authorParanhos, António
dc.contributor.authorCruz, Maria Teresa
dc.contributor.authorCastel-Branco, Margarida
dc.contributor.authorFigueiredo, I. Vitória
dc.contributor.authorBatista, Maria Teresa
dc.date.accessioned2017-11-06T15:04:44Z
dc.date.available2017-11-06T15:04:44Z
dc.date.issued2017
dc.description.abstractAgrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MS (n) . To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively. Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSANTOS, Telmo N. [et al.] - Antioxidant, anti-inflammatory, and analgesic activities of agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine. ISSN. 1741-427X. (2017) p. 1-13pt_PT
dc.identifier.doi10.1155/2017/8309894pt_PT
dc.identifier.issn1741-427X
dc.identifier.urihttp://hdl.handle.net/10400.11/5736
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relationFEDER/COMPETE (FCOMP-01-0124-FEDER-011096)pt_PT
dc.relationFCT Project PTDC/SAU-FCF/105429/2008pt_PT
dc.relationFCT Project PEst-OE/SAU/UI0177/2011pt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/ecam/2017/8309894/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgrimonia eupatoria L.pt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectAnalgesic activitypt_PT
dc.titleAntioxidant, anti-inflammatory, and analgesic activities of agrimonia eupatoria L. Infusionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEvidence-Based Complementary and Alternative Medicinept_PT
oaire.citation.volume2017pt_PT
person.familyNameLiberal
person.givenNameJoana
person.identifier1606413
person.identifier.ciencia-id9814-C8C3-E713
person.identifier.orcid0000-0003-0161-9617
person.identifier.scopus-author-id36604847500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4c4126f6-ce52-4388-86c4-88c4d34adccd
relation.isAuthorOfPublication.latestForDiscovery4c4126f6-ce52-4388-86c4-88c4d34adccd

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