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Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries

2022Journal article Open access
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dc.contributor.authorNunes, Elsa
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorNunes, Sara
dc.contributor.authorMoutinho, José Fonseca
dc.date.accessioned2024-12-10T09:49:34Z
dc.date.available2024-12-10T09:49:34Z
dc.date.issued2022
dc.description.abstractThis study aims to clarify the effect of postmenopausal bilateral oophorectomy on plasma steroid hormone levels. Women who were submitted in the postmenopausal period to hysterectomy for uterine benign conditions were divided into two groups: 18 women had isolated hysterectomy and 11 had hysterectomy with bilateral salpingo-oophorectomy. In both groups serum hormone levels were quantified by solid phase extraction and gas chromatography and tandem mass spectrometry. Differences in dehydroepiandrosterone (DHEA), testosterone, androstenedione and oestradiol were determined in both groups. The analysis revealed lower steroid levels in the bilateral salpingo-oophorectomy group when compared to the isolated hysterectomy group with statistically significant differences found for DHEA (5.8 ± 3.2 vs. 9.4 ± 4.4 ng/mL; p ¼ 0.019) and oestradiol (0.69 ± 0.4 vs. 1.48 ± 4.3 ng/mL; p ¼ 0.007). The results are consistent with a significant endocrine activity of the postmenopausal ovary. The clinical consequences of these findings need to be clarified and postmenopausal prophylactic bilateral salpingo-oophorectomy re-evaluated.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes, E., Gallardo, E., Morgado-Nunes, S., & Fonseca-Moutinho, J. (2022). Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries. Journal of Obstetrics and Gynaecology, 43(1). https://doi.org/10.1080/01443615.2022.2141618pt_PT
dc.identifier.doi10.1080/01443615.2022.2141618pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/9222
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMenopausept_PT
dc.subjectOophorectomypt_PT
dc.subjectAndrogenspt_PT
dc.subjectOestrogenspt_PT
dc.subjectDehydroepiandrosteronept_PT
dc.subjectIntracrinologypt_PT
dc.titleSteroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovariespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleJournal of Obstetrics and Gynaecologypt_PT
oaire.citation.volume43pt_PT
person.familyNameNunes
person.familyNameGallardo
person.familyNameNunes
person.givenNameElsa
person.givenNameEugenia
person.givenNameSara
person.identifier.ciencia-idF617-5CA5-EF61
person.identifier.ciencia-id131C-F496-B174
person.identifier.orcid0000-0003-2214-8033
person.identifier.orcid0000-0002-1802-8998
person.identifier.orcid0000-0003-2944-306X
person.identifier.scopus-author-id54416082400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4ea5feda-b26a-4f3d-9c53-0a031990b3eb
relation.isAuthorOfPublication813b1412-acc9-471c-9358-f6d9e904cbf1
relation.isAuthorOfPublicationb58bc557-35e1-4f5a-9753-78478a18790a
relation.isAuthorOfPublication.latestForDiscoveryb58bc557-35e1-4f5a-9753-78478a18790a

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