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Publication
Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries
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Advisor(s)
Abstract(s)
This study aims to clarify the effect of postmenopausal bilateral oophorectomy on plasma steroid hormone levels. Women who were submitted in the postmenopausal period to hysterectomy for uterine
benign conditions were divided into two groups: 18 women had isolated hysterectomy and 11 had
hysterectomy with bilateral salpingo-oophorectomy. In both groups serum hormone levels were quantified by solid phase extraction and gas chromatography and tandem mass spectrometry. Differences in
dehydroepiandrosterone (DHEA), testosterone, androstenedione and oestradiol were determined in
both groups. The analysis revealed lower steroid levels in the bilateral salpingo-oophorectomy group
when compared to the isolated hysterectomy group with statistically significant differences found for
DHEA (5.8 ± 3.2 vs. 9.4 ± 4.4 ng/mL; p ¼ 0.019) and oestradiol (0.69 ± 0.4 vs. 1.48 ± 4.3 ng/mL; p ¼ 0.007).
The results are consistent with a significant endocrine activity of the postmenopausal ovary. The clinical
consequences of these findings need to be clarified and postmenopausal prophylactic bilateral salpingo-oophorectomy re-evaluated.
Description
Keywords
Menopause Oophorectomy Androgens Oestrogens Dehydroepiandrosterone Intracrinology
Pedagogical Context
Citation
Nunes, E., Gallardo, E., Morgado-Nunes, S., & Fonseca-Moutinho, J. (2022). Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries. Journal of Obstetrics and Gynaecology, 43(1). https://doi.org/10.1080/01443615.2022.2141618
Publisher
Taylor & Francis