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Neuropathology of animal prion diseases

2021Journal article Open access
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dc.contributor.authorOrge, Leonor
dc.contributor.authorLima, Carla
dc.contributor.authorMachado, Carla
dc.contributor.authorTavares, Paula
dc.contributor.authorMendonça, Paula
dc.contributor.authorCarvalho, Paulo
dc.contributor.authorSilva, João
dc.contributor.authorPinto, Maria de Lurdes
dc.contributor.authorBastos, Estela
dc.contributor.authorPereira, Jorge C.
dc.contributor.authorGonçalves-Anjo, Nuno
dc.contributor.authorGama, Adelina
dc.contributor.authorEsteves, Alexandra
dc.contributor.authorAlves, Anabela
dc.contributor.authorMatos, Ana Cristina
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorSilva, Filipe
dc.contributor.authorPires, Isabel
dc.contributor.authorFigueira, Luís
dc.contributor.authorPinto, Madalena Vieira
dc.contributor.authorSargo, Roberto
dc.contributor.authorPires, Maria dos Anjos
dc.date.accessioned2022-01-05T12:10:46Z
dc.date.available2022-01-05T12:10:46Z
dc.date.issued2021
dc.description.abstractTransmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrPC) into a misfolded pathological isoform (PrPSc or prion- proteinaceous infectious particle) that self-propagates by conformational conversion of PrPC. Yet by an unknown mechanism, PrPC can fold into different PrPSc conformers that may result in different prion strains that display specific disease phenotype (incubation time, clinical signs and lesion profile). Although the pathways for neurodegeneration as well as the involvement of brain inflammation in these diseases are not well understood, the spongiform changes, neuronal loss, gliosis and accumulation of PrPSc are the characteristic neuropathological lesions. Scrapie affecting small ruminants was the first identified TSE and has been considered the archetype of prion diseases, though atypical and new animal prion diseases continue to emerge highlighting the importance to investigate the lesion profile in naturally affected animals. In this report, we review the neuropathology and the neuroinflammation of animal prion diseases in natural hosts from scrapie, going through the zoonotic bovine spongiform encephalopathy (BSE), the chronic wasting disease (CWD) to the newly identified camel prion disease (CPD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOrge, L.; Lima, C.; Machado, C.; Tavares, P.; Mendonça, P.; Carvalho, P.; Silva, J.; Pinto, M.; Bastos, E.; Pereira, J.; Gonçalves-Anjo, N.; Gama, A.; Esteves, A.; Alves, A.; Matos, A.; Seixas, F.; Silva, F.; Pires, I.; Figueira, L.; Vieira-Pinto, M.; Sargo, R.; Pires, M. Neuropathology of Animal Prion Diseases. Biomolecules 2021, 11(3), 466; https://doi.org/10.3390/biom11030466.pt_PT
dc.identifier.doi10.3390/biom11030466pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/7801
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationChronic Wasting Disease Risk Assessment in Portugal
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTransmissible Spongiform Encephalopathiespt_PT
dc.subjectPrPScpt_PT
dc.subjectChronic wasting diseasept_PT
dc.subjectPrion diseasespt_PT
dc.titleNeuropathology of animal prion diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChronic Wasting Disease Risk Assessment in Portugal
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FCVT-CVT%2F29947%2F2017/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage466pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameRibeiro Pinto
person.familyNameMatos
person.familyNameFigueira
person.givenNameMaria de Lurdes
person.givenNameAna
person.givenNameLuís Manuel Faria
person.identifier.ciencia-idE81F-5A9E-5C8D
person.identifier.ciencia-id2711-E07A-FE45
person.identifier.ciencia-id941B-C381-8158
person.identifier.orcid0000-0002-5928-6483
person.identifier.orcid0000-0001-9709-862X
person.identifier.orcid0000-0002-8454-2880
person.identifier.ridK-6664-2013
person.identifier.scopus-author-id55626078200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationb6aa356b-8fa0-42be-af99-b34818a15cdc
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