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Calcium dobesilate Is protective against Inflammation and oxidative/nitrosative stress in the retina of a type 1 diabetic rat model

2017Journal article Restricted access
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dc.contributor.authorVoabil, Paula
dc.contributor.authorLiberal, Joana
dc.contributor.authorLeal, Ermelindo C.
dc.contributor.authorBauer, Jacques
dc.contributor.authorVaz, José Cunha
dc.contributor.authorSantiago, Ana Raquel
dc.contributor.authorAmbrósio, António Francisco
dc.date.accessioned2017-11-15T12:45:45Z
dc.date.available2017-11-15T12:45:45Z
dc.date.issued2017
dc.description.abstractCalcium dobesilate (CaD) has been prescribed to some patients in the early stages of diabetic retinopathy to delay its progression. We previously reported that the treatment of diabetic animals (4 weeks of diabetes) with CaD, during the last 10 days of diabetes, prevents blood-retinal barrier breakdown. Here, we aimed to investigate whether later treatment of diabetic rats with CaD would reverse inflammatory processes in the retina. Diabetes was induced with streptozotocin, and 6 weeks after diabetes onset, CaD (100 mg/kg/day) was administered for 2 weeks. The treatment with CaD significantly increased glial fibrillary acidic protein (GFAP) levels in the retina of nondiabetic animals (138.6 ± 12.8% of control) and enhanced the diabetes-induced increase in GFAP levels (174.8 ± 5.6% of control). In addition, CaD prevented the increase in mRNA and protein expression of tumor necrosis factor and interleukin-1β, as well as the formation of oxidized carbonyl residues and the increase in nitrotyrosine immunoreactivity, particularly in the ganglion cell layer of diabetic animals. We demonstrate that the treatment of diabetic animals with CaD can reverse the established proinflammatory processes in the retina. These beneficial effects appear to be attributed, at least partially, to the antioxidant properties of CaD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVOABIL, Paula [et al.] (2017) - Calcium dobesilate Is protective against Inflammation and oxidative/nitrosative stress in the retina of a type 1 diabetic rat model. Ophthalmic Research. ISSN 0030-3747. Vol. 58, nº 3, p. 150-161.pt_PT
dc.identifier.doi10.1159/000478784pt_PT
dc.identifier.issn0030-3747
dc.identifier.urihttp://hdl.handle.net/10400.11/5740
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKarger Publisherspt_PT
dc.relationPEst-C/SAU/ UI3282/2011-2013pt_PT
dc.relation.publisherversionhttps://www.karger.com/Article/Abstract/478784pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCalcium dobesilatept_PT
dc.subjectDiabetic retinopathypt_PT
dc.subjectInflammationpt_PT
dc.subjectCytokinespt_PT
dc.subjectOxidative stresspt_PT
dc.subjectNitrosative stresspt_PT
dc.titleCalcium dobesilate Is protective against Inflammation and oxidative/nitrosative stress in the retina of a type 1 diabetic rat modelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage161pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage150pt_PT
oaire.citation.titleOphthalmic Researchpt_PT
oaire.citation.volume58pt_PT
person.familyNameLiberal
person.givenNameJoana
person.identifier1606413
person.identifier.ciencia-id9814-C8C3-E713
person.identifier.orcid0000-0003-0161-9617
person.identifier.scopus-author-id36604847500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4c4126f6-ce52-4388-86c4-88c4d34adccd
relation.isAuthorOfPublication.latestForDiscovery4c4126f6-ce52-4388-86c4-88c4d34adccd

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