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Browsing by Author "Rodrigues, Carla"

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  • Fourier transform infrared (FT-IR) spectroscopy typing: a real-time analysis of an outbreak by carbapenem-resistant Klebsiella pneumoniae
    Publication . Silva, Liliana; Rodrigues, Carla; Lira, Agostinho; Leão, Mariana; Mota, Margarida; Lopes, Paulo; Novais, Ângela; Peixe, Luísa
    The spread of multidrug-resistant (MDR) Klebsiella pneumoniae in the nosocomial setting represents a big challenge to infection control teams. We have recently developed a simple spectroscopic-based method with excellent accuracy, turnaround time and cost-effectiveness (Rodrigues et al. mSystems 2020) for bacterial typing. Here, we applied our method in a real clinical context to support early identification of an outbreak involving KPC-3-producing K. pneumoniae ST147 isolates. Our results further support that attenuated total reflectance Fourier transform infrared (FT-IR) spectroscopy can provide enough information to support early and adequate infection control measures and therapeutic choices in the context of nosocomial outbreaks and hospital surveillance.
    2020Journal article Restricted access Show more
  • The success of particular acinetobacter baumannii clones: accumulating resistance and virulence inside a sugary shield
    Publication . Silva, Liliana; Grosso, Filipa; Rodrigues, Carla; Ksiezarek, Magdalena; Ramos, Helena; Peixe, Luísa
    In Portugal, carbapenem-resistant Acinetobacter baumannii (CRAB) has been associated with ST98, ST103 and ST208 (Oxford Scheme, Oxf) and a clone has usually been associated with a particular period of time. These clonal shifts were primarily explained by an increased antimicrobial resistance profile. Here we explore genomic and biochemical differences among these and more recent clones, which could further explain the diversity and evolution of this species.
    2020Journal article Restricted access Show more