EVOLUTION AND DYNAMICS OF MULTIDRUG RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES FROM HOSPITAL AND COMMUNITY SETTINGS

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Fourier transform infrared (FT-IR) spectroscopy typing: a real-time analysis of an outbreak by carbapenem-resistant Klebsiella pneumoniae

Publication . Silva, Liliana; Rodrigues, Carla; Lira, Agostinho; Leão, Mariana; Mota, Margarida; Lopes, Paulo; Novais, Ângela; Peixe, Luísa

The spread of multidrug-resistant (MDR) Klebsiella pneumoniae in the nosocomial setting represents a big challenge to infection control teams. We have recently developed a simple spectroscopic-based method with excellent accuracy, turnaround time and cost-effectiveness (Rodrigues et al. mSystems 2020) for bacterial typing. Here, we applied our method in a real clinical context to support early identification of an outbreak involving KPC-3-producing K. pneumoniae ST147 isolates. Our results further support that attenuated total reflectance Fourier transform infrared (FT-IR) spectroscopy can provide enough information to support early and adequate infection control measures and therapeutic choices in the context of nosocomial outbreaks and hospital surveillance.

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Fundação para a Ciência e a Tecnologia

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SFRH/BD/84341/2012