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Mesenteric lymph node granulomatous lesions in naturally infected wild boar (Sus scrofa) in Portugal--Histological, immunohistochemical and molecular aspects

2016Journal article Restricted access
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dc.contributor.authorMatos, Ana Cristina
dc.contributor.authorAndrade, S.
dc.contributor.authorFigueira, Luís
dc.contributor.authorMatos, Manuela
dc.contributor.authorPires, Maria dos Anjos
dc.contributor.authorCoelho, Ana Cláudia
dc.contributor.authorPinto, Maria de Lurdes
dc.date.accessioned2017-05-15T22:26:31Z
dc.date.available2017-05-15T22:26:31Z
dc.date.issued2016
dc.description.abstractSeveral studies have demonstrated that wildlife reservoirs of mycobacteria are responsible for the maintenance and spreading of the infection to livestock and wildlife counterparts. Recent data report the role of wild boar (Sus scrofa) as a reservoir for Mycobacterium bovis. This study was conducted to evaluate the chronic inflammatory response in the mesenteric lymph nodes (MLN) of wild boar with granulomatous lymphadenitis (n=30). Morphological parameters of the lesions were recorded. The expression of CD3 and CD79α molecules was evaluated by immunohistochemistry. Molecular genotyping and culture to identify mycobacteria were performed. The lesions consisted mainly of stage III and stage IV granulomas. CD3 and CD79α positive cells were observed in 15 (50%) and in 11 (36.6%) MLN, respectively. In these lesions, higher percentages of T lymphocytes were found and a limited number of animals exhibited a tendency for an increased percentage of B lymphocytes. Our results suggest that there are similar percentages and distribution patterns of CD3 and CD79α in the lesions, regardless of the presence of Mycobacterium avium subsp. paratuberculosis (Map), M. bovis or Map-M. bovis co-infection, and confirm that wild boar is both susceptible and could be an important Map and M. bovis wild reservoir in the study area.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatos, A.C., Andrade, S., Figueira, L., Matos, M., Pires, M.A., Coelho, A.C., Pinto M.L., 2016. Mesenteric lymph node granulomatous lesions in naturally infected wild boar (Sus scrofa) in Portugal - Histological, immunohistochemical and molecular aspects. Veterinary Immunology and Immunopathology 173: 21-26.pt_PT
dc.identifier.doi10.1016/j.vetimm.2016.03.012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/5550
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectMesenteric lymph nodespt_PT
dc.subjectMycobacteriosispt_PT
dc.subjectWild boarpt_PT
dc.subjectSus scrofapt_PT
dc.titleMesenteric lymph node granulomatous lesions in naturally infected wild boar (Sus scrofa) in Portugal--Histological, immunohistochemical and molecular aspectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage26pt_PT
oaire.citation.startPage21pt_PT
oaire.citation.volume173pt_PT
person.familyNameMatos
person.familyNameFigueira
person.familyNamede Matos
person.familyNameCoelho
person.familyNameRibeiro Pinto
person.givenNameAna
person.givenNameLuís Manuel Faria
person.givenNameMaria Manuela Outeiro
person.givenNameAna
person.givenNameMaria de Lurdes
person.identifier84738
person.identifier.ciencia-id2711-E07A-FE45
person.identifier.ciencia-id941B-C381-8158
person.identifier.ciencia-id4F1E-ACFF-86CB
person.identifier.ciencia-id1E10-BF40-29C5
person.identifier.ciencia-idE81F-5A9E-5C8D
person.identifier.orcid0000-0001-9709-862X
person.identifier.orcid0000-0002-8454-2880
person.identifier.orcid0000-0002-9584-6636
person.identifier.orcid0000-0002-7196-4179
person.identifier.orcid0000-0002-5928-6483
person.identifier.ridK-6664-2013
person.identifier.ridK-4740-2013
person.identifier.scopus-author-id55626078200
person.identifier.scopus-author-id34970835100
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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