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Short-term high-intensity resistance training: A feasibility study on pulmonary, immune and physical-functional fitness benefits for older adults with metabolic syndrome

2025Research article Open access
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dc.contributor.authorSantos, Juliana de Melo Batista dos
dc.contributor.authorFurtado, Guilherme Eustáquio
dc.contributor.authorCorrea, Eviton Sousa
dc.contributor.authorRangel, Maysa Alves Rodrigues Brandao
dc.contributor.authorJunior, Manoel Carneiro Oliveira
dc.contributor.authorCardoso, Katielle Rodrigues da Silva
dc.contributor.authorSouza, Mariana Alvarez de
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorCoelho, Patricia
dc.contributor.authorOliveira, Luís Vicente Franco de
dc.contributor.authorBachi, André Luís Lacerda
dc.contributor.authorJorge, Luciana Malosa Sampaio
dc.contributor.authorMartins, Patrícia Sardinha Leonardo Lopes
dc.contributor.authorAlbertini, Regiane
dc.contributor.authorVieira, Rodolfo P.
dc.date.accessioned2025-09-19T11:39:07Z
dc.date.available2025-09-19T11:39:07Z
dc.date.issued2025
dc.date.updated2025-09-16T08:47:17Z
dc.descriptionAcknowledgements: This study was supported by Sao Paulo Research Foundation (FAPESP), grant #2012/15165-2 and by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grant #308434/2022-6. RMF holds a MSc fellowship from FAPESP (#2019/11008-9). MARBR holds a PhD fellowship from FAPESP (#2019/05739-0). The author G.E.F. thanks the National funding by FCT- Foundation for Science and Technology, P.I., through the institutional scientific employment program-contract CEECINST/00077/2021).
dc.description.abstractThe incidence of metabolic syndrome (MetS) is rising rapidly, particularly among older adults, and is associated with comorbidities that impair respiratory and immune functions. Physical exercise has proven effective in mitigating the adverse effects of both aging and MetS. However, evidence on the impact of high-intensity resistance training (HIRT) on the respiratory and immune systems in older adults with MetS remains limited. This study aimed to evaluate the effects of HIRT on respiratory function, skeletal muscle strength, and immune modulation in older adults with MetS, highlighting its potential as a complementary therapeutic approach. A total of 43 older adults with MetS were enrolled and divided into two groups: a HIRT intervention group (n = 23; mean age 66.71 ± 4.98 years) and a non-exercising control group (n = 20; mean age 66.91 ± 5.26 years). The HIRT protocol involved twice-weekly sessions (10 total) over 5 weeks, performed at 80–90% of one-repetition maximum. Results showed that HIRT significantly improved lung mechanics (R5Hz, R20Hz, Z5Hz, X5Hz), peripheral muscle strength, and both maximal expiratory and inspiratory pressures. Furthermore, HIRT increased antiinflammatory and anti-fibrotic cytokines in sputum (klotho, IL-10, adiponectin) and serum (klotho, relaxin-1, relaxin-3, IL-10), while reducing pro-inflammatory cytokines in sputum (IL-6, TNF-α) and serum (IL-1ra, IL-6, TNF-α, leptin). A decrease in total leukocyte, neutrophil, lymphocyte, and monocyte counts was also observed. In conclusion, HIRT effectively mitigates the effects of MetS on respiratory, muscular, and immune functions in older adults and may be recommended as a complementary strategy for managing MetS in this population.eng
dc.description.sponsorshipOpen access funding provided by FCT|FCCN (b-on). FAPESP, 2019/05739-0, Maysa Alves Rodrigues Brandao-Rangel, 2012/15165-2, Juliana de Melo Batista Santos, 2019/11008-9, Conselho Nacional de Desenvolvimento Científico e Tecnológico, 308434/2022-6, Juliana de Melo Batista Santos.
dc.description.versionN/A
dc.identifier.citationSANTOS, J.M.B. [et al.] (2025) - Short-term high-intensity resistance training: A feasibility study on pulmonary, immune and physical-functional fitness benefits for older adults with metabolic syndrome. European Journal of Applied Physiology. DOI: 10.1007/s00421-025-05920-0
dc.identifier.doi10.1007/s00421-025-05920-0en_US
dc.identifier.slugcv-prod-4564164
dc.identifier.urihttp://hdl.handle.net/10400.11/10303
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAging
dc.subjectImmune system
dc.subjectLung mechanics
dc.subjectMetabolic syndrome
dc.subjectResistance training
dc.titleShort-term high-intensity resistance training: A feasibility study on pulmonary, immune and physical-functional fitness benefits for older adults with metabolic syndromeeng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Applied Physiologyen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameCoelho
person.givenNameFrancisco
person.givenNamePatricia
person.identifier2982790
person.identifier.ciencia-id7A18-045E-330C
person.identifier.ciencia-id231C-F92A-1BC2
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication30f36b8c-0bee-46cd-9ecf-be2a8dc33bd6
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

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