Repository logo
 
Publication

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review

2019Journal article Open access
Simple item page
dc.contributor.authorBonacho, T.
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorLiberal, Joana
dc.date.accessioned2019-10-10T17:15:44Z
dc.date.available2020-12-31T01:30:22Z
dc.date.issued2019
dc.description“This is an Accepted Manuscript of an article published by Taylor & Francis in Biotechnic and Histochemistry on 10 Sep 2019, available at http://www.tandfonline.com/10.1080/10520295.2019.1651901."pt_PT
dc.description.abstractBreast cancer is the most prevalent malignant tumor and main oncologic cause of mortality in women. Although most diagnosis of breast pathology is accomplished using hematoxylin and eosin stained sections, some cases require immunohistochemistry for proper evaluation. We investigated the latter cases including distinctions between ductal and lobular carcinoma, in situ and invasive carcinoma, typical ductal hyperplasia and atypical ductal hyperplasia/ductal carcinoma in situ, papillary and spindle cell lesion assessment, metastasis evaluation, and assessment of prognostic and therapy markers. E-cadherin is used to differentiate ductal and lobular carcinoma; 34βE12, CK8, p120 catenin and β-catenin also produce consistent results. Myoepithelial cell (MEC) stains are used to evaluate in situ and invasive carcinoma; calponin, smooth muscle myosin heavy chain and p63 are sensitive/specific markers. 34βE12 and CK5/6 are positive in ductal hyperplasia, which enables its differentiation from atypical ductal hyperplasia and ductal carcinoma in situ. CK 5/6, ER and MEC markers are consistent options for evaluating papillary lesions. Spindle cell lesions can be assessed using β-catenin, SMA, CD34, p63, CKs and hormone receptors. It is important to differentiate primary carcinomas from metastases; the most commonly used markers to identify breast origin include mammaglobin, GCDFP-15, GATA3 and ER, although none of these is completely sensitive or specific. Immunohistochemistry can be used to evaluate central prognostic and predictive factors including molecular subtypes, HER2, hormone receptors, proliferation markers (Ki-67) and lymph-vascular invasion markers including ERG, CD31, CD34, factor VIII and podoplanin. Owing to the complexity of mammary lesions, diagnosis also depends on each particular situation, evaluation of cytological characteristics revealed by immunochemistry and correlation with histological findings.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationBONACHO, T. ; Rodrigues, F.; Liberal, J. (2019) - Immunohistochemistry for diagnosis and prognosis of breast cancer: a review. Biotechnic and Histochemistry. ISSN 1473-7760. DOI: 10.1080/10520295.2019.1651901pt_PT
dc.identifier.doi10.1080/10520295.2019.1651901pt_PT
dc.identifier.issn1052-0295 (Print)
dc.identifier.issn1473-7760 (Online)
dc.identifier.urihttp://hdl.handle.net/10400.11/6675
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/pdf/10.1080/10520295.2019.1651901pt_PT
dc.subjectBreastpt_PT
dc.subjectCancerpt_PT
dc.subjectDiagnosispt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectPrognosispt_PT
dc.subjectReviewpt_PT
dc.titleImmunohistochemistry for diagnosis and prognosis of breast cancer: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage21pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiotechnic and Histochemistrypt_PT
person.familyNameRodrigues
person.familyNameLiberal
person.givenNameFrancisco
person.givenNameJoana
person.identifier2982790
person.identifier1606413
person.identifier.ciencia-id7A18-045E-330C
person.identifier.ciencia-id9814-C8C3-E713
person.identifier.orcid0000-0001-8405-4249
person.identifier.orcid0000-0003-0161-9617
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
person.identifier.scopus-author-id36604847500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication4c4126f6-ce52-4388-86c4-88c4d34adccd
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Immunohistochemistry for diagnosis and prognosis of breast cancer_A.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.02 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESALD - Artigos em revistas com arbitragem científica