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Prevalence, determinants, and temporal dynamics of multidrug-resistant Gram-negative bacilli in urinary tract infection patients from Central Portugal (2018–2022)

2026Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAdnan, Muhammad
dc.contributor.authorCoelho, Patricia
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorRodrigues, Francisco
dc.date.accessioned2026-02-03T17:24:15Z
dc.date.available2026-02-03T17:24:15Z
dc.date.issued2026
dc.date.updated2026-02-03T12:29:55Z
dc.descriptionData Availability Statement: The data forms part of a database that can be made available for consultation, based on plausible justifications. All data is anonymized.
dc.description.abstractBackground: Multidrug-resistant (MDR) Gram-negative bacilli (GNBs) significantly compromisse the effective management of urinary tract infections (UTIs) worldwide. As antimicrobial resistance varies across regions, locally tailored data are essential to guide empirical therapy. This study investigated the prevalence, determinants, and temporal dynamics of MDR GNBs in UTI patients from Central Portugal between 2018 and 2022. Methods:We conducted a retrospective observational study at a hospital center in Central Portugal, analyzing data from 2018 to 2022. Data from 5194 UTI patients with GNB-positive cultures were analyzed. Binary logistic regression was used to identify determinants of MDR GNBs, defined as resistance to ≥1 agent in ≥3 antibiotic classes. Results: The study population had a mean age of 64.5 ± 25.3 years, and females represented two-thirds of the sample (67.0%). The overall prevalence of MDR GNBs was 35.8%. Advanced age (≥75 years), male sex, and specific treatment contexts—particularly day treatment and laboratory-only cases—were independently associated with MDR. SBL-producing Enterobacterales and non-fermenting GNBs showed the highest risk levels. Conclusions: MDR GNBs are highly prevalent among UTI patients in Central Portugal, and their increasing trend—particularly in 2022—highlights an urgent need for strengthened surveillance and updated empirical treatment strategies. The observed temporal increase highlights the urgent need for strengthened regional surveillance and updated empirical treatment guidelines.eng
dc.description.versionN/A
dc.identifier.citationADNAN, Muhammad [et al.] (2026) - Prevalence, determinants, and temporal dynamics of multidrug-resistant Gram-negative bacilli in urinary tract infection patients from Central Portugal (2018–2022). Bacteria. DOI: 10.3390/bacteria5010008
dc.identifier.doi10.3390/bacteria5010008en_US
dc.identifier.slugcv-prod-4707137
dc.identifier.urihttp://hdl.handle.net/10400.11/10513
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.subjectAnti-bacterial agents
dc.subjectDrug resistance
dc.subjectGram-negative bacteria
dc.subjectPortugal
dc.subjectUrinary tract infections
dc.titlePrevalence, determinants, and temporal dynamics of multidrug-resistant Gram-negative bacilli in urinary tract infection patients from Central Portugal (2018–2022)eng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleBacteriaen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoelho
person.familyNameRodrigues
person.givenNamePatricia
person.givenNameFrancisco
person.identifier2982790
person.identifier.ciencia-id231C-F92A-1BC2
person.identifier.ciencia-id7A18-045E-330C
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublication30f36b8c-0bee-46cd-9ecf-be2a8dc33bd6
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

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