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Epidemiological profile and antibiotic resistance in urinary tract infections among elderly women

2025Research article Open access
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dc.contributor.authorRodrigues, Francisco
dc.contributor.authorPatricia Coelho
dc.contributor.authorMateus, Sónia
dc.contributor.authorMetello, João
dc.contributor.authorCastelo-Branco, Miguel
dc.date.accessioned2025-09-19T10:34:02Z
dc.date.available2025-09-19T10:34:02Z
dc.date.issued2025
dc.date.updated2025-09-16T08:52:53Z
dc.descriptionDue to ethical restrictions and the protection of participants’ confidentiality, the data are not publicly available. However, the datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
dc.description.abstractUrinary tract infections (UTIs) are among the most prevalent infectious diseases in older women, especially those over 65 years of age. Physiological changes related to aging, comorbidities, and frequent use of medical devices such as urinary catheters increase susceptibility. Increasing antimicrobial resistance further complicates treatment strategies. This study aims to describe the epidemiological profile of UTI in women over 65 years of age, focusing on the characterization of etiological agents, observed antimicrobial resistance patterns, and commonly reported risk factors. We conducted a retrospective analysis of microbiological and clinical data from elderly women diagnosed with UTIs. Bacterial isolates were identified and antimicrobial susceptibility profiles were evaluated over a specified period. A statistical analysis was performed to determine the prevalence of different pathogens and antibiotic resistance trends. Escherichia coli was the predominant uropathogen, consistent across different clinical scenarios and patient conditions. The four most common bacterial strains—E. coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterococcus faecalis—aligned with global epidemiological data. In Escherichia coli a significant increase in resistance to nitrofurantoin was observed, possibly indicating excessive empirical use, while resistance to other antibiotics, such as amoxicillin/clavulanic acid and ertapenem, remained stable or decreased. Institutional antibiotic stewardship programs likely contributed to this trend. The study highlights E. coli as the main etiological agent in elderly women with UTIs. The observed resistance patterns emphasize the need for localized antimicrobial surveillance and personalized therapeutic approaches. Continuous microbiological monitoring and rational use of antibiotics are crucial to optimize treatment outcomes and control the development of resistance.por
dc.description.versionN/A
dc.identifier.citationRODRIGUES, F.J.B. [et al.] (2025) - Epidemiological profile and antibiotic resistance in urinary tract infections among elderly women. Women. Vol. 5, n.º 16. DOI: 10.3390/women5020016
dc.identifier.doi10.3390/women5020016en_US
dc.identifier.slugcv-prod-4564162
dc.identifier.urihttp://hdl.handle.net/10400.11/10301
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectUrinary tract infections (UTIs)
dc.subjectAntibiotic resistance
dc.subjectAntibiotic stewardship
dc.subjectEpidemiology of UTIs
dc.subjectElderly women
dc.titleEpidemiological profile and antibiotic resistance in urinary tract infections among elderly womenen_US
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleWomenen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameCoelho
person.givenNameFrancisco
person.givenNamePatricia Margarida dos Santos Carvalheiro
person.identifier2982790
person.identifier.ciencia-id7A18-045E-330C
person.identifier.ciencia-idFC1B-BB26-3206
person.identifier.orcid0000-0001-8405-4249
person.identifier.orcid0000-0002-9862-0691
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublicationaf807030-f5b4-4634-a7c5-77749716e4f8
relation.isAuthorOfPublication.latestForDiscoveryaf807030-f5b4-4634-a7c5-77749716e4f8

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