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Effects of multicomponent exercise on immunity, antibodies, and physical activity in older adults after COVID-19 vaccination: An RCT-feasibility study

2026Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Médicas
dc.contributor.authorFerreira, Bruna Maria Palotino
dc.contributor.authorFurtado, Guilherme Eustáquio
dc.contributor.authorGomes, Antonio Felipe Souza
dc.contributor.authorAmaral, Jônatas Bussador do
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorSilva, Albená Nunes
dc.contributor.authorRossiMarcelo
dc.contributor.authorBachi, André Luís Lacerda
dc.contributor.authorOliveira, Juliana da Silva
dc.contributor.authorSantos, Clarice Alves dos
dc.contributor.authorVasconcelos, Saulo
dc.date.accessioned2026-08-07T15:58:23Z
dc.date.available2026-08-07T15:58:23Z
dc.date.issued2026
dc.date.updated2026-08-07T14:07:14Z
dc.description.abstractBackground Immunosenescence contributes to reduced vaccine responsiveness and chronic low-grade inflammation in olderadults. Although regular physical exercise has been associated with improved immune function, evidence regarding thefeasibility and immunological effects of multicomponent exercise training (MET) following COVID-19 vaccinationremains limited. This pilot randomized feasibility trial aimed to assess the feasibility of implementing a 10-week METprogram and to explore its effects on functional fitness, physical activity, anthropometric measures, lipid profile, andimmuno-inflammatory markers in community-dwelling older adults after COVID-19 vaccination. Methods Twenty-three community-dwelling older adults (≥60 years) completed this randomized pilot feasibility trial and wereallocated to either a MET group (n = 10) or a Behavior Change Program (BCP) group (n = 13). Both interventions lasted10 weeks. Pre- and post-intervention assessments included functional fitness (Short Physical Performance Battery),physical activity levels, anthropometric measures, lipid and protein profiles, immunoglobulins (IgA, IgM, IgG), andcytokines (IL-2, IL-6, IL-10, TNF-α, and IFN-γ). Results The intervention proved feasible, with satisfactory adherence among participants completing the program and noexercise-related adverse events. The MET group demonstrated significant improvements in functional fitness (p =0.002; d = 1.90). Although physical activity levels showed a positive trend, changes did not reach statistical significance.Significant reductions in IL-2, IL-6, and TNF-α were observed following MET (all p ≤ 0.05), whereas the BCP groupexhibited increased IL-6 concentrations together with higher IL-2/IL-10 and IL-6/IL-10 ratios, suggesting a shift towarda more pro-inflammatory profile. Moderate-to-large effect sizes were also observed for improvements in selected lipidparameters, although most biochemical changes were not statistically significant. Conclusions This pilot feasibility trial demonstrated that a 10-week multicomponent exercise program can be safely implementedin community-dwelling older adults following COVID-19 vaccination and provides preliminary evidence of beneficialeffects on functional fitness and selected immuno-inflammatory markers. Given the small sample size, these findingsshould be interpreted cautiously and confirmed in adequately powered randomized controlled trials.eng
dc.description.versionN/A
dc.identifier.citationFERREIRA, Bruna Maria Palotino [et al.] (2026) - Effects of multicomponent exercise on immunity, antibodies, and physical activity in older adults after COVID-19 vaccination: An RCT-feasibility study.Journal of Bodywork and Movement Therapies. DOI: 10.1016/j.jbmt.2026.07.035
dc.identifier.doi10.1016/j.jbmt.2026.07.035en_US
dc.identifier.slugcv-prod-5083878
dc.identifier.urihttp://hdl.handle.net/10400.11/10968
dc.language.isoeng
dc.peerreviewedyes
dc.rights.uriN/A
dc.subjectCommunity-dwelling
dc.subjectExercise immunology
dc.subjectImmunoglobulin
dc.subjectInflammaging
dc.subjectPhysical function
dc.subjectVaccine
dc.titleEffects of multicomponent exercise on immunity, antibodies, and physical activity in older adults after COVID-19 vaccination: An RCT-feasibility studyeng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleJournal of Bodywork and Movement Therapiesen_US
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa
person.familyNameRodrigues
person.givenNameFrancisco
person.identifier2982790
person.identifier.ciencia-id7A18-045E-330C
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

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