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The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults : a systematic review and meta-analysis

2024Journal article Open access
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dc.contributor.authorSilva, Fernanda
dc.contributor.authorDuarte-Mendes, Pedro
dc.contributor.authorTeixeira, Ana
dc.contributor.authorSoares, Carlos M.
dc.contributor.authorFerreira, José P.
dc.date.accessioned2024-07-30T08:55:40Z
dc.date.available2024-07-30T08:55:40Z
dc.date.issued2024
dc.description.abstractThis systematic review and meta-analysis aimed to determine the magnitude of the effect of combined exercise training on glucose metabolism markers, adipokines, and inflammatory cytokines in non-diabetic sedentary adults. PubMed, Web of Science, Scopus, Cochrane Library electronic databases and reference lists of included studies were explored for randomized controlled trials (RCTs) that included physically inactive adults and provided combined training interventions (aerobic plus resistance exercise). Effects on fasting glucose and insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), HbA1c, adiponectin, leptin, IL-6, TNF-α, and C-reactive protein (CRP) in exercise vs control groups were analyzed using random effects meta-analysis. The Cochrane Risk of Bias Tool for Randomized Trials 2.0 (RoB 2) was used to assess the risk of bias. A total of 24 RCTs were included in the quantitative analysis. Combined exercise training significantly decrease fasting glucose (standardized mean difference, SMD: − 0.474, 95% CI [− 0.829, − 0.120], p = 0.009, 35 study arms), fasting insulin (SMD: − 1.024, 95% CI [− 1.502, − 0.545], p < 0.001, 27 study arms), HOMA-IR (SMD: − 0.946, 95% CI [− 1.450, − 0.442], p < 0.001, 23 study arms), TNF-α (SMD: − 0.972, 95% CI [− 1.361, − 0.582], p < 0.001, 10 study arms), and CRP (SMD: − 0.507, 95% CI [− 0.818, − 0.196], p = 0.001, 14 study arms). No significant effects were observed for HbA1c, adiponectin, leptin, and IL-6 levels. Random effects meta-regression models by age, sex, and intervention length were not able to explain any of the variation in the effect size of HOMA-IR. Findings from this systematic review and meta-analysis suggest that combined exercise training improves some glucose metabolism markers and inflammatory parameters in sedentary adults without diabetes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, F. M., Duarte-Mendes, P., Teixeira, A. M., Soares, C. M., & Ferreira, J. P. (2024) - The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis. Scientific reports, 14(1). DOI: 10.1038/s41598-024-51832-ypt_PT
dc.identifier.doi10.1038/s41598-024-51832-ypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/9077
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationPortuguese Foundation for Science and Technology (2020.08759.BD).pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSedentary adultspt_PT
dc.subjectCombined exercise trainingpt_PT
dc.subjectGlucose metabolism and inflammatory markerspt_PT
dc.subjectSystematic review and meta-analysispt_PT
dc.titleThe effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults : a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage35pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume14pt_PT
person.familyNameAntunes da Silva
person.familyNameDuarte-Mendes
person.familyNameMiranda Botelho Teixeira
person.familyNameLeitão Ferreira
person.givenNameFernanda Maria
person.givenNamePedro
person.givenNameAna Maria
person.givenNameJosé Pedro
person.identifierrid7830
person.identifier.ciencia-id3B13-1E85-181F
person.identifier.ciencia-idBB19-DC8E-05C7
person.identifier.ciencia-id4B15-EC24-6644
person.identifier.ciencia-id661D-14B5-A499
person.identifier.orcid0000-0001-8019-0729
person.identifier.orcid0000-0001-5055-2696
person.identifier.orcid0000-0003-1498-949X
person.identifier.orcid0000-0002-4427-3276
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication21bba01a-01a5-4aab-83b4-ff740fb29219
relation.isAuthorOfPublicationc4872844-d6f5-49d8-891c-a1a13e00ffc6
relation.isAuthorOfPublication6988bdf5-05d4-4fe7-9f87-4b4d395fef86
relation.isAuthorOfPublication29bf49eb-3e65-4660-b604-6936f7d68afa
relation.isAuthorOfPublication.latestForDiscoveryc4872844-d6f5-49d8-891c-a1a13e00ffc6

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