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The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19

2025Research article Open access
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dc.contributor.authorFerreira, Bruna Maria Palotino
dc.contributor.authorRocha, Saulo Vasconcelos
dc.contributor.authorSilva, Albená Nunes
dc.contributor.authorGomes, Antonio Felipe Souza
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorCoelho, Patricia
dc.contributor.authorBachi, André Luís Lacerda
dc.contributor.authorOliveira, Rodrigo Assunção de
dc.contributor.authorBarros, Marcelo Paes de
dc.contributor.authorFurtado, Guilherme Eustáquio
dc.date.accessioned2025-10-31T15:21:18Z
dc.date.available2025-10-31T15:21:18Z
dc.date.issued2025
dc.date.updated2025-10-30T21:57:13Z
dc.description.abstractBackground: Amidst the ongoing COVID-19 pandemic, understanding factors that influence vaccine efficacy is crucial, particularly in older adults. Regular physical exercise and/or structured physical activity (SPA) has emerged as a potential modulator of immune responses, enhancing vaccine effectiveness. This systematic review aims to consolidate current evidence on the impact of SPA/exercise on both immune and inflammatory responses to COVID-19 vaccination in adults and older individuals. Methods: Most relevant studies were extracted from indexed databases using health subject terms in English, Portuguese, and Spanish. Studies that examined the impact of regular exercise or SPA on inflammatory and/or immunological responses in relation to COVID-19 immunization were selected. In particular, all chosen studies included individuals who received vaccinations either prior to or following the exercise regimen or SPA, and the main goal was to evaluate these effects on immunological and/or inflammatory reactions induced by vaccination. Results: Among the 7 studies included (n = 1149), the effects of regular exercise or PA on vaccine-induced imune responses while concurrently assessing inflammatory markers were examined. The findings suggest that moderate to high-intensity structured physical activity (50–70% of maximum heart rate for aerobic exercise and 60–80% of 1RM for resistance training), performed 3–5 times per week, was able to enhance immune responses to COVID-19 vaccination, particularly by mitigating chronic low-grade inflammation. Acute exercise can transiently boost immunity, whilst engagement in moderate SPA over a period of six months may contribute to sustained improvements in imune function, especially in older adults. However, these findings should be interpreted with caution due to variability in study design, sample characteristics, and potential confounding factors. Conclusion: Regular exercise and SPA play a significant role in improving immune/inflammatory responses to COVID-19 vaccination. Older adults, in particular, may benefit from regular SPA and exercise as a strategy to counteract immunosenescence and optimize vaccine efficacy. However, further research is needed to better refine exerciseprotocols and determine long-term benefits in different populations.eng
dc.description.versionN/A
dc.identifier.citationFERREIRA, Bruna Maria Palotino [et al.] (2025) - The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19. Immunity & Ageing. 22:44. DOI: 10.1186/s12979-025-00515-x Immunity & Ageing
dc.identifier.doi10.1186/s12979-025-00515-xen_US
dc.identifier.slugcv-prod-4591744
dc.identifier.urihttp://hdl.handle.net/10400.11/10346
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBMC
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectUpper respiratory tract infector
dc.subjectJ-Shaped curve
dc.subjectPsychobiological stress
dc.subjectPhysical exerciseC CovFlu vaccines
dc.titleThe influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19eng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleImmunity & Ageingen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameCoelho
person.givenNameFrancisco
person.givenNamePatricia
person.identifier2982790
person.identifier.ciencia-id7A18-045E-330C
person.identifier.ciencia-id231C-F92A-1BC2
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication30f36b8c-0bee-46cd-9ecf-be2a8dc33bd6
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

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