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Volatilomics as an emerging strategy to determine potential biomarkers of female infertility: a pilot study
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Orientador(es)
Resumo(s)
Due to its high prevalence, infertility has become a prominent public health issue, posing a
significant challenge to modern reproductive medicine. Some clinical conditions that lead to female
infertility include polycystic ovary syndrome (PCOS), endometriosis, and premature ovarian failure
(POF). Follicular fluid (FF) is the biological matrix that has the most contact with the oocyte and
can, therefore, be used as a predictor of its quality. Volatilomics has emerged as a non-invasive,
straightforward, affordable, and simple method for characterizing various diseases and determining
the effectiveness of their current therapies. In order to find potential biomarkers of infertility, this
study set out to determine the volatomic pattern of the follicular fluid from patients with PCOS,
endometriosis, and POF. The chromatographic data integration was performed through solid-phase
microextraction (SPME), followed by gas chromatography–mass spectrometry (GC-MS). The findings
pointed to specific metabolite patterns as potential biomarkers for the studied diseases. These
open the door for further research into the relevant metabolomic pathways to enhance infertility
knowledge and diagnostic tools. An extended investigation may, however, produce a new mechanistic
understanding of the pathophysiology of the diseases.
Descrição
Palavras-chave
Infertility Polycystic ovary syndrome Endometriosis Premature ovarian failure Follicular fluid Volatile organic compounds Solid-phase microextraction Gas chromatography–mass spectrometry
Contexto Educativo
Citação
BRINCA, A.T. [et al.] (2022) - Volatilomics as an emerging strategy to determine potential biomarkers of female infertility: a pilot study. Biomedicines. 10, p. 2852. DOI: 10.3390/biomedicines10112852
Editora
MDPI