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Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infection

2024Journal article Open access
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dc.contributor.authorLindo, Jorge
dc.contributor.authorNogueira, Célia
dc.contributor.authorSoares, Rui
dc.contributor.authorCunha, Nuno
dc.contributor.authorAlmeida, Maria Rosário
dc.contributor.authorRodrigues, Lisa
dc.contributor.authorCoelho, Patrícia
dc.contributor.authorRodrigues, Francisco
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorGonçalves, Teresa O.
dc.date.accessioned2024-06-26T16:35:37Z
dc.date.available2024-06-26T16:35:37Z
dc.date.issued2024
dc.description.abstractSARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and genotypic frequencies of a loss-of-function SNP of ADORA2A (rs2298383) and a gain-of-function single nucleotide polymorphism (SNP) of P2RX7 (rs208294) in the severity of SARS-CoV-2-associated infection. Fifty-five individuals were enrolled and categorized according to the severity of the infection. Endpoint genotyping was performed in blood cells to screen for both SNPs. The TT genotype (vs. CT + CC) and the T allele (vs. C allele) of P2RX7 SNP were found to be associated with more severe forms of COVID-19, whereas the association between ADORA2A SNP and the severity of infection was not significantly different. The T allele of P2RX7 SNP was more frequent in people with more than one comorbidity and with cardiovascular conditions and was associated with colorectal cancer. Our findings suggest a more prominent role of P2X7R rather than of A2AR polymorphisms in SARS-CoV-2 infection, although larger population-based studies should be performed to validate our conclusions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLINDO, Jorge [et al.] (2024) - Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infection. International Journal of Molecular Sciences. 11:25, p.6135. DOI: https://doi.org/10.3390/ijms25116135pt_PT
dc.identifier.doi10.3390/ijms25116135pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/9029
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdenosine A2A receptorpt_PT
dc.subjectATP P2X7 receptorpt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectPolymorphismspt_PT
dc.titleGenetic polymorphisms of P2RX7 but not of ADORA2A are associated with the severity of SARS-CoV-2 infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage6135pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25pt_PT
person.familyNameCoelho
person.familyNameRodrigues
person.familyNameGonçalves
person.givenNamePatricia Margarida dos Santos Carvalheiro
person.givenNameFrancisco
person.givenNameTeresa
person.identifier2982790
person.identifier308557
person.identifier.ciencia-idFC1B-BB26-3206
person.identifier.ciencia-id7A18-045E-330C
person.identifier.ciencia-idA111-3A90-E501
person.identifier.orcid0000-0002-9862-0691
person.identifier.orcid0000-0001-8405-4249
person.identifier.orcid0000-0001-9347-0535
person.identifier.ridJTV-3288-2023
person.identifier.ridF-5146-2011
person.identifier.scopus-author-id57214122402
person.identifier.scopus-author-id35874075200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationaf807030-f5b4-4634-a7c5-77749716e4f8
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication2f2465a2-5b72-4619-9885-060a93f97191
relation.isAuthorOfPublication.latestForDiscoveryd496c83f-3a6b-424e-ba10-452ce609d597

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