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TSE monitoring in wildlife epidemiology, transmission, diagnosis, genetics and control

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dc.contributor.authorMachado, Carla
dc.contributor.authorOrge, Leonor
dc.contributor.authorPires, Isabel
dc.contributor.authorGama, Adelina
dc.contributor.authorEsteves, Alexandra
dc.contributor.authorMendonça, Paula
dc.contributor.authorMatos, Ana Cristina
dc.contributor.authorAlves, Anabela
dc.contributor.authorLima, Carla
dc.contributor.authorBastos, Estela
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorSilva, Filipe
dc.contributor.authorSilva, João
dc.contributor.authorFigueira, Luís
dc.contributor.authorPinto, Madalena Vieira
dc.contributor.authorPinto, Maria de Lurdes
dc.contributor.authorGonçalves-Anjo, Nuno
dc.contributor.authorTavares, Paula
dc.contributor.authorCarvalho, Paulo
dc.contributor.authorSargo, Roberto
dc.contributor.authorPires, Maria dos Anjos
dc.date.accessioned2019-11-23T00:05:41Z
dc.date.available2019-11-23T00:05:41Z
dc.date.issued2019
dc.description.abstractAmong the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now the rising concern within Europe. CWD will be outlined in this chapter gathering its epidemiology, transmission, diagnosis, genetics, and control. Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of an abnormal isoform of the prion protein (PrPc), usually designated by PrPsc or prion. CWD is a prion disease of natural transmission affecting cervids detected mainly in North America. The first European case was detected in Norway, in 2016, in a wild reindeer; until April 2018, a total of 23 cases were described. The definite diagnosis is postmortem, performed in target areas of the brain and lymph nodes. Samples are first screened using a rapid test and, if positive, confirmed by immunohistochemistry and Western immunoblotting. It is not possible to establish a culling plan based on the genotype, once affected animals appear with all genotypes. However, some polymorphisms seem to result in longer incubation periods or confer a reduced risk. The control is not easy in captive cervids and even more in the wildlife; some recommendations have been proposed in order to understand the danger and impact of CWD on animal and public health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado, C.N., Orge L., Pires, I., Gama, A., Esteves, A., Mendonça, A.P., Matos, A.C., Anabela Alves, A., Lima, C., Bastos, E., Seixas, F., Silva, F., Silva, J.C., Figueira, L, Vieira-Pinto, M, Pinto, M.L., Gonçalves-Anjo, N., Tavares, P., Carvalho, P., Sargo R., Pires, M.A.,2019. TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control [Online First], IntechOpen, (April 30th 2019). DOI: 10.5772/intechopen.85797.pt_PT
dc.identifier.doi10.5772/intechopen.85797pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/6774
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIntechOpenpt_PT
dc.subjectPrionpt_PT
dc.subjectCervidspt_PT
dc.subjectChronic wasting diseasept_PT
dc.subjectPRNPpt_PT
dc.subjectGenepathologypt_PT
dc.titleTSE monitoring in wildlife epidemiology, transmission, diagnosis, genetics and controlpt_PT
dc.typebook part
dspace.entity.typePublication
person.familyNameMatos
person.familyNameFigueira
person.familyNameRibeiro Pinto
person.givenNameAna
person.givenNameLuís Manuel Faria
person.givenNameMaria de Lurdes
person.identifier.ciencia-id2711-E07A-FE45
person.identifier.ciencia-id941B-C381-8158
person.identifier.ciencia-idE81F-5A9E-5C8D
person.identifier.orcid0000-0001-9709-862X
person.identifier.orcid0000-0002-8454-2880
person.identifier.orcid0000-0002-5928-6483
person.identifier.ridK-6664-2013
person.identifier.scopus-author-id55626078200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationb6aa356b-8fa0-42be-af99-b34818a15cdc
relation.isAuthorOfPublication74ef6ec4-da08-461e-a861-a4f5beb24858
relation.isAuthorOfPublicatione1a553fd-7452-47c4-a87d-f5863dd02746
relation.isAuthorOfPublication.latestForDiscovery74ef6ec4-da08-461e-a861-a4f5beb24858

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