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Changes in metabolic and inflammatory markers after a combined exercise program in workers : a randomized controlled trial

2024Journal article Open access
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dc.contributor.authorSilva, Fernanda
dc.contributor.authorDuarte-Mendes, Pedro
dc.contributor.authorFerreira, José P.
dc.contributor.authorCarvalho, Eugénia
dc.contributor.authorMonteiro, Diogo
dc.contributor.authorMassart, Alain
dc.contributor.authorFarinha, Carlos
dc.contributor.authorSoares, Carlos M.
dc.contributor.authorTeixeira, Ana
dc.date.accessioned2024-07-30T08:51:05Z
dc.date.available2024-07-30T08:51:05Z
dc.date.issued2024
dc.description.abstractPurpose: We investigated the effects of a 16-week combined exercise training on body composition, metabolic and inflammatory markers in sedentary middle-aged workers. We also assessed whether significant alterations in metabolic markers were associated with changes in health-related outcomes. Methods: This randomized controlled trial involved 46 participants randomly allocated into control and exercise groups. The exercise group performed 16-week combined aerobic and resistance training for 75 min/session, 3 times/week. Fasting blood samples were collected at baseline and after 16-week intervention to determine lipid profile, metabolic and inflammatory markers as primary outcomes. Results: A total of 36 participants completed the intervention (53.70 ± 6.92 years old) (n = 18 in each group). Waist circumference (interaction effect: F = 7.423, p = 0.002), fat mass (interaction effect: F = 5.070, p = 0.011), and muscle mass (interaction effect: F = 5.420, p = 0.007) were improved in the exercise group compared to the control group. Fasting glucose increased after the 16-week follow-up (time effect: F = 73.253, p < 0.001), without an intergroup difference. Insulin levels were greater in the control compared to exercise group (group effect: F = 6.509, p = 0.015). The control group tended to increase the HOMA-IR index (interaction effect: F = 3.493, p = 0.070) and to decrease the QUICKI index (interaction effect: F = 3.364, p = 0.075) to a greater extent compared to the exercise group. Exercise group reduced leptin (interaction effect: F = 11.175, p = 0.002) and adiponectin (interaction effect: F = 4.437, p = 0.043) concentrations in a greater magnitude than control group. IL-6 (time effect: F = 17.767, p < 0.001) and TNF-α (time effect: F = 9.781, p = 0.004) concentrations decreased after the intervention, without an intergroup difference. IL-17A levels increased in the control compared to exercise group (interaction effect: F = 5.010, p = 0.033). Effects on adiponectin, IL-6 and IL-17A levels seem to depend on baseline BMI, age, and sex. Percentage changes in leptin correlated positively with changes in HOMA-IR index in the exercise (r = 0.565, p = 0.015) and control (r = 0.670, p = 0.002) groups. Conclusions: A combined training program can be an effective strategy to improve body composition and inflammatory markers and prevent marked reductions in insulin sensitivity among middle-aged workers.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationSilva, F. M., Duarte-Mendes, P., Ferreira, J. P., Carvalho, E., Monteiro, D., Massart, A., Farinha, C., Soares, C. M., & Teixeira, A. M. (2024). Changes in metabolic and inflammatory markers after a combined exercise program in workers : a randomized controlled trial. Medicine and science in sports and exercise. Advance online publication. DOI: 10.1249/MSS.0000000000003510pt_PT
dc.identifier.doi10.1249/MSS.0000000000003510pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/9076
dc.language.isoengpt_PT
dc.publisherAmerican College of Sports Medicinept_PT
dc.relationPortuguese Foundation for Science and Technology (2020.08759. BD).pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCombined Exercise Programpt_PT
dc.subjectMetabolic and Inflammatory Markerspt_PT
dc.subjectRandomized Controlled Trialpt_PT
dc.titleChanges in metabolic and inflammatory markers after a combined exercise program in workers : a randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMedicine & Science in Sports & Exercisept_PT
person.familyNameAntunes da Silva
person.familyNameDuarte-Mendes
person.familyNameLeitão Ferreira
person.familyNameMonteiro
person.familyNameNunes Farinha
person.familyNameMiranda Botelho Teixeira
person.givenNameFernanda Maria
person.givenNamePedro
person.givenNameJosé Pedro
person.givenNameDiogo
person.givenNameCarlos Manuel
person.givenNameAna Maria
person.identifierrid7830
person.identifierF-1202-2015
person.identifier.ciencia-id3B13-1E85-181F
person.identifier.ciencia-idBB19-DC8E-05C7
person.identifier.ciencia-id661D-14B5-A499
person.identifier.ciencia-idED1F-6228-E26F
person.identifier.ciencia-idCD19-424E-F14F
person.identifier.ciencia-id4B15-EC24-6644
person.identifier.orcid0000-0001-8019-0729
person.identifier.orcid0000-0001-5055-2696
person.identifier.orcid0000-0002-4427-3276
person.identifier.orcid0000-0002-7179-6814
person.identifier.orcid0000-0003-1498-949X
person.identifier.scopus-author-id56437945500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication21bba01a-01a5-4aab-83b4-ff740fb29219
relation.isAuthorOfPublicationc4872844-d6f5-49d8-891c-a1a13e00ffc6
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relation.isAuthorOfPublication.latestForDiscovery29bf49eb-3e65-4660-b604-6936f7d68afa

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