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Enzyme inhibitory potential of Ligustrum lucidum Aiton berries

2019Journal article Open access
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dc.contributor.authorPaula, Vanessa Branco
dc.contributor.authorDelgado, Teresa
dc.contributor.authorCampos, Maria da Graça
dc.contributor.authorAnjos, O.
dc.contributor.authorEstevinho, Letícia M.
dc.date.accessioned2019-06-20T23:42:49Z
dc.date.available2019-06-20T23:42:49Z
dc.date.issued2019
dc.description.abstractLigustrum lucidum Aiton and its berries have been used in Chinese traditional medicine for around two thousand years. In the present study, L. lucidium berries harvested in two regions of Portugal were studied. Haemolytic activity and inhibition of oxidative haemolysis as well as the enzyme inhibitory activities (α-amylase enzyme and acetylcholinesterase) were assessed. Results suggest that the different biological activities varied according to the region where samples were collected. Results demonstrated that the sample obtained from region R1 was the most efficient extract for all parameters evaluated, presenting the lowest values of IC50, 10.67 ± 0.46 μg/mL for the inhibition of erythrocyte oxidative haemolysis, 58.28 ± 3.77 μg/mL for the α-amylase enzyme and 67.67 ± 2.10 μg/mL for the acetylcholinesterase inhibition. L. Lucidum berries may be an interesting source of compounds for use in the development of the therapeutic armamentarium for diseases where enzymatic disruption is believed to play a rolept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules24071283pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.11/6552
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectLigustrum lucidumpt_PT
dc.subjectAiton berriespt_PT
dc.subjectDiabetespt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectEnzyme inhibitory potentialpt_PT
dc.titleEnzyme inhibitory potential of Ligustrum lucidum Aiton berriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPage1283pt_PT
oaire.citation.volume24pt_PT
person.familyNameAnjos
person.familyNameMiranda Fernandes Estevinho
person.givenNameOfélia
person.givenNameMaria Leticia
person.identifier.ciencia-idC21D-D8C7-3037
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0003-0267-3252
person.identifier.orcid0000-0002-9249-1948
person.identifier.ridG-2808-2012
person.identifier.scopus-author-id23395659700
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdf9191ae-0bbb-4bb8-bbdc-0f79c7365876
relation.isAuthorOfPublication833b19a5-a9f2-485d-a48d-4ead7bdd3f0d
relation.isAuthorOfPublication.latestForDiscoverydf9191ae-0bbb-4bb8-bbdc-0f79c7365876

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