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Publication
Steroid hormone levels and bone mineral density in women over 65 years of age
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Advisor(s)
Abstract(s)
Previous studies using immunoassays for steroid measurements have focused on the association
between steroid hormone levels and bone mineral density (BMD) in postmenopausal women,
obtaining contradictory results. This study aimed to assess this association using a highly sensitive
bioanalytical method. A total of 68 postmenopausal women, aged 65–89 years, were enrolled in
a crosssectional study. Measurements of the BMD of the hip and lumbar spine were performed
using dual energy Xray absorptiometry, and serum hormone levels were quantifed by gas
chromatography and tandem mass spectrometry. Associations between estradiol (E2), testosterone,
dehydroepiandrosterone (DHEA), androstenedione and T score levels of the hip and lumbar spine were
evaluated, after adjustment for confounding variables. The analysis revealed a statistically signifcant
association between testosterone and the T score of the hip (p= 0.035), but not that of the lumbar
spine. No statistically signifcant associations were found between E2, DHEA, androstenedione and
the T scores of the hip and the lumbar spine. Using a highly sensitive hormone assay method, our
study identifed a signifcant association between testosterone and BMD of the hip in women over
65 years of age, suggesting that lower testosterone increases the risk of osteoporosis.
Description
Keywords
Steroid hormone levels Bone mineral density Women over 65 years
Citation
Nunes, E., Gallardo, E., Morgado-Nunes, S. et al. Steroid hormone levels and bone mineral density in women over 65 years of age. Sci Rep 13, 4925 (2023). https://doi.org/10.1038/s41598-023-32100-x
Publisher
Nature