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Bioactivity of Matricaria chamomilla, Echinacea purpurea, Thymbra capitata and Ocimum basilicum hydrolates and essential oils in view of their application in the skin

2026Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
dc.contributor.authorValente, João Vasco
dc.contributor.authorGomes, Carolina Proença
dc.contributor.authorOliveira, Ana Sofia
dc.contributor.authorRolo, Joana
dc.contributor.authorGaspar, Carlos
dc.contributor.authorCaramelo, Débora
dc.contributor.authorGonçalves, José Carlos
dc.contributor.authorDelgado, F.M.G.
dc.contributor.authorBreitenfeld, Luisa
dc.contributor.authorDuarte, Ana Paula
dc.contributor.authorOliveira, Rita Palmeira de
dc.contributor.authorOliveira, José Martinez de
dc.contributor.authorOliveira, Ana Palmeira de
dc.date.accessioned2026-04-08T09:24:23Z
dc.date.available2026-04-08T09:24:23Z
dc.date.issued2026
dc.date.updated2026-04-06T17:54:30Z
dc.description.abstractThe numerous health benefits associated with the use of plants in traditional medicine can be linked to secondary metabolites in the products obtained through the hydrodistillation process, such as hydrolates and essential oils (EOs). This study aimed to assess the chemical profile and the antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities of two hydrodistillation products obtained from four plants belonging to two distinct families: chamomile (Matricaria chamomilla), purple coneflower (Echinacea purpurea), conehead thyme (Thymbra capitata), and basil (Ocimum basilicum). The EOs were found to be more effective than hydrolates in inhibiting microorganisms’ growth, registering MIC values equal to or higher than 50% (v/v), except for T. capitata. Only T. capitata demonstrated the ability to reduce NO levels with both hydrolate and EO. Moreover, it inhibited the cell growth of RAW 264.7, 3T3, and HaCaT lines at the tested concentrations. In contrast, O. basilicum EO did not affect the cell proliferation of the tested cell lines in concentrations below 0.063% (v/v) and showed a significant reduction in the macrophage NO production at all concentrations. Thus, EOs showed a superior biological activity than hydrolates. In particular, O. basilicum EO was found to be a promising candidate for therapeutic applications on the skin.eng
dc.description.sponsorshipThis research was funded by “INOVEP project—Innovation with Plant Extracts”, I&DT projects for companies in collaboration with scientific entities, project number 33815, Centro2020 and by Foundation for Science and Technology (FCT), through funds from the State Budget, and by the European Regional Development Fund (ERDF), under the Portugal 2020 Program, through the Regional Operational Program of the Center (Centro2020), through the Project with the reference UIDB/00709/2020.
dc.description.versionN/A
dc.identifier.citationVALENTE, João Vasco [et al.] (2026) - Bioactivity of Matricaria chamomilla, Echinacea purpurea, Thymbra capitata and Ocimum basilicum hydrolates and essential oils in view of their application in the skin. Molecules. DOI: 10.3390/molecules31071156
dc.identifier.doi10.3390/molecules31071156en_US
dc.identifier.slugcv-prod-5011677
dc.identifier.urihttp://hdl.handle.net/10400.11/10811
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUID/00681/2025en_US
dc.relation10.54499/UID/00681/2025en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAromatic plants
dc.subjectBioactive compounds
dc.subjectMicrobial growth
dc.subjectCytotoxicity
dc.subjectFree radicals
dc.titleBioactivity of Matricaria chamomilla, Echinacea purpurea, Thymbra capitata and Ocimum basilicum hydrolates and essential oils in view of their application in the skineng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.titleMoleculesen_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCaramelo
person.familyNameGonçalves
person.familyNameDelgado
person.givenNameDébora
person.givenNameJosé
person.givenNameF.M.G.
person.identifier1959038
person.identifier508085
person.identifier.ciencia-idEA1D-EF0D-F6B7
person.identifier.ciencia-idAE1F-12BE-65DD
person.identifier.ciencia-idC715-76B6-A07D
person.identifier.orcid0000-0002-6135-9645
person.identifier.orcid0000-0003-3387-4487
person.identifier.orcid0000-0003-1238-9386
person.identifier.scopus-author-id57210150152
person.identifier.scopus-author-id7103325479
rcaap.cv.cienciaidC715-76B6-A07D | Fernanda Maria Grácio Delgado Ferreira de Sousa
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationaed78127-f9c7-44bd-b407-cb2101a6b97c
relation.isAuthorOfPublication3f401604-ccbb-45f3-8ee1-05063cf3d60a
relation.isAuthorOfPublication8ae072f8-0aa1-46ce-830a-210c42f9e11b
relation.isAuthorOfPublication.latestForDiscovery3f401604-ccbb-45f3-8ee1-05063cf3d60a

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