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Determinants of multidrug resistance among gram-positive uropathogens in Central Portugal: A 5 year retrospective study

2026Artigo de investigação Acesso aberto
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datacite.subject.fosCiências Médicas
dc.contributor.authorAdnan, Muhammad
dc.contributor.authorPatricia Coelho
dc.contributor.authorMateus, Sónia
dc.contributor.authorCastelo Branco, Miguel
dc.contributor.authorRodrigues, Francisco
dc.date.accessioned2026-08-06T11:32:17Z
dc.date.available2026-08-06T11:32:17Z
dc.date.issued2026
dc.date.updated2026-08-01T10:09:23Z
dc.description.abstractUrinary tract infections (UTIs) are among the most common bacterial infections worldwide. Although Gram-negative bacteria predominate, Gram-positive cocci (GPC) are increasingly recognized as significant uropathogens. This retrospective study analyzed 655 patients with culture-confirmed GPC UTIs in a hospital in Central Portugal (2018–2022) to identify predictors of multidrug resistance (MDR). MDR was defined as resistance to three or more antimicrobial classes. The overall MDR prevalence was 83.7%, with Enterococcus spp. showing the highest MDR prevalence (98.2%). Multivariate analysis identified older age as na independent predictor of MDR, whereas Staphylococcus and Streptococcus species were associated with significantly lower odds compared to Enterococcus. A temporal increase in MDR risk was observed in 2021 and 2022. Despite the high overall resistance rates observed, oxazolidinones and cyclic lipopeptides retained near-complete activity against all GPC isolates, reinforcing their role as last-line therapeutic options.eng
dc.description.sponsorshipThis study was funded by the SPRINT: Sport Physical Activity and Health Research and Innovation Center (Centro de Investigação e 8472, 2026, 1, Downloaded from https://onlinelibrary.wiley.com/doi/10.1155/ijm/1664980 by Francisco Rodrigues - Cochrane Portugal , Wiley Online Library on [01 /08/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License 10 of 12 International Journal of Microbiology, 2026 Inovação em Desporto Atividade Física e Saúde, Portugal) and the FCT: Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) (UID/06185/2025 [10.54499/UID/06185/2025], UID/PRR/06185/2025 [10.54499/UID/PRR/06185/2025], and UID/ PRR2/06185/2025).
dc.description.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.citationADNAN, Muhammad [et al.] (2026) - Determinants of multidrug resistance among gram-positive uropathogens in Central Portugal : A 5 year retrospective study. International Journal of Microbiology. Vol. 26:1. DOI: 10.1155/ijm/1664980
dc.identifier.doi10.1155/ijm/1664980en_US
dc.identifier.issn1687-918Xen_US
dc.identifier.issn1687-9198en_US
dc.identifier.slugcv-prod-5081329
dc.identifier.urihttp://hdl.handle.net/10400.11/10962
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntibacterial agentes
dc.subjectAntimicrobial stewardship
dc.subjectGram-positive cocci
dc.subjectPortugal
dc.subjectUrinary tract infections
dc.titleDeterminants of multidrug resistance among gram-positive uropathogens in Central Portugal: A 5 year retrospective studyeng
dc.typeresearch articleen_US
dspace.entity.typePublication
oaire.citation.issue1en_US
oaire.citation.titleInternational Journal of Microbiologyen_US
oaire.citation.volume2026en_US
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoelho
person.familyNameRodrigues
person.givenNamePatricia Margarida dos Santos Carvalheiro
person.givenNameFrancisco
person.identifier2982790
person.identifier.ciencia-idFC1B-BB26-3206
person.identifier.ciencia-id7A18-045E-330C
person.identifier.orcid0000-0002-9862-0691
person.identifier.orcid0000-0001-8405-4249
person.identifier.ridJTV-3288-2023
person.identifier.scopus-author-id57214122402
rcaap.cv.cienciaid7A18-045E-330C | Francisco José Barbas Rodrigues
rcaap.rightsopenAccessen_US
relation.isAuthorOfPublicationaf807030-f5b4-4634-a7c5-77749716e4f8
relation.isAuthorOfPublicationd496c83f-3a6b-424e-ba10-452ce609d597
relation.isAuthorOfPublication.latestForDiscoveryaf807030-f5b4-4634-a7c5-77749716e4f8

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