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Orientador(es)
Resumo(s)
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. Although Gram-negative bacteria predominate, Gram-positive cocci (GPC) are increasingly recognized as significant uropathogens. This retrospective study analyzed 655 patients with culture-confirmed GPC UTIs in a hospital in Central Portugal (2018–2022) to identify predictors of multidrug resistance (MDR). MDR was defined as resistance to three or more antimicrobial classes. The overall MDR prevalence was 83.7%, with Enterococcus spp. showing the highest MDR prevalence (98.2%). Multivariate analysis identified older age as na independent predictor of MDR, whereas Staphylococcus and Streptococcus species were associated with significantly lower odds
compared to Enterococcus. A temporal increase in MDR risk was observed in 2021 and 2022. Despite the high overall resistance rates observed, oxazolidinones and cyclic lipopeptides retained near-complete activity against all GPC isolates, reinforcing their role as last-line therapeutic options.
Descrição
Palavras-chave
Antibacterial agentes Antimicrobial stewardship Gram-positive cocci Portugal Urinary tract infections
Contexto Educativo
Citação
ADNAN, Muhammad [et al.] (2026) - Determinants of multidrug resistance among gram-positive uropathogens in Central Portugal : A 5 year retrospective study. International Journal of Microbiology. Vol. 26:1. DOI: 10.1155/ijm/1664980
Editora
Wiley