Talaromyces marneffeiisolated from nasal swabs in Portugal

Matos, Manuela; Baptista, Catarina Jota; Oliveira, Paula A.; Matos, Ana Cristina; Soares, Ana Sofia; Santos, Marlene; Figueira, Luís; Coelho, Ana Cláudia

http://hdl.handle.net/10400.11/8747

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Authors

Matos, Manuela

Baptista, Catarina Jota

Abstract(s)

Mycobiota are essential to the health of any living being, creating a balanced and complex interaction between bacteria, the immune system, and the tissue cells of the host. Talaromyces marneffei (also known as Penicillium marneffei) is a dimorphic fungus, endemic in South Asia, which often causes a life-threatening systemic fungal infection (called penicilliosis), particularly in immunocompromised hosts. Nasal swabs from 73 healthy volunteers were analysed to characterize their mycobiota, through its cultural characteristics, morphology, and molecular methods (PCR). All volunteers were also asked to answer to an anonymous questionnaire. Three women were positive (and asymptomatic) for T. marneffei. One of them was reported to have lupus. This study contributes to improving our knowledge about human normal mycobiota, identifying mycotic agents that may cause complicated systemic infections (as T. marneffei), especially in immunosuppressed patients, as well as other possible risk factors of exposure or prognosis.

Keywords

Fungi Mycobiota Nasal mucosa Talaromyces marneffiei Penicilliosis

URI

http://hdl.handle.net/10400.11/8747

Citation

MATOS, Catarina Jota Baptista [et al.] (2023) - Talaromyces marneffei isolated from nasal swabs in Portugal. Medical Mycology. Vol. 61, Issue 4, myad031. DOI: https://doi.org/10.1093/mmy/myad031