The influence of pericardial fat on left ventricular diastolic function

Coelho, Patrícia; Duarte, Hugo; Alcafache, Carlos; Rodrigues, Francisco

Publication

The influence of pericardial fat on left ventricular diastolic function

2024Journal article

dc.contributor.author	Coelho, Patrícia
dc.contributor.author	Duarte, Hugo
dc.contributor.author	Alcafache, Carlos
dc.contributor.author	Rodrigues, Francisco
dc.date.accessioned	2024-05-23T14:28:28Z
dc.date.available	2024-05-23T14:28:28Z
dc.date.issued	2024
dc.description.abstract	Abstract: Background: Heart failure is a major cause of morbidity and mortality worldwide; left ventricular diastolic dysfunction plays a leading role in this clinical context. Diastolic dysfunction may be predisposed by increased abdominal fat and, consequently, increased pericardial and epicardial adiposity. This study aimed to determine whether pericardial fat (PF) and epicardial fat (EF) are associated with left ventricular diastolic function. Methods: A total of 82 patients had their abdominal circumference measured and underwent transthoracic echocardiography to measure the thickness of PF and EF and assess the left ventricular diastolic function. Two groups were created based on mean pericardial fat (PF) thickness (4.644 mm) and were related to abdominal circumference and echocardiographic parameters. Results: Subjects in the PF High group showed a significant decrease in septal e’ (p < 0.0001), lateral e’ (p < 0.0001), and E/A ratio (p = 0.003), as well as a significant increase in E/e’ ratio (p < 0.0001), E wave deceleration time (p = 0.013), left atrial volume (p < 0.0001), the left ventricle mass (p = 0.003), tricuspid regurgitant jet velocity (p < 0.0001), and the left ventricle diameter (p = 0.014) compared to the PF Low group. Correlations were found between pericardial fat and nine echocardiographic parameters in the study, while epicardial fat (EP) only correlated with eight. Conclusions: Measurement of abdominal circumference, PF, and EF is an early indicator of diastolic changes with transthoracic echocardiography being the gold standard exam.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	COELHO, Patrícia [et al.] (2024) - The influence of pericardial fat on left ventricular diastolic function. Diagbnostics. Vol. 14, 702. DOI: https://doi.org/10.3390/diagnostics14070702	pt_PT
dc.identifier.doi	10.3390/diagnostics14070702	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.11/8995
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	MDPI	pt_PT
dc.relation.publisherversion	https://www.mdpi.com/2075-4418/14/7/702	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Pericardium	pt_PT
dc.subject	Echocardiography	pt_PT
dc.subject	Ventricular dysfunction	pt_PT
dc.subject	Heart failure	pt_PT
dc.subject	Diastolic	pt_PT
dc.subject	Abdominal circumference	pt_PT
dc.title	The influence of pericardial fat on left ventricular diastolic function	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.startPage	702	pt_PT
oaire.citation.title	Diagnostics	pt_PT
oaire.citation.volume	14	pt_PT
person.familyName	Coelho
person.familyName	Alcafache
person.familyName	Rodrigues
person.givenName	Patricia Margarida dos Santos Carvalheiro
person.givenName	Carlos
person.givenName	Francisco
person.identifier	2982790
person.identifier.ciencia-id	FC1B-BB26-3206
person.identifier.ciencia-id	7A18-045E-330C
person.identifier.orcid	0000-0002-9862-0691
person.identifier.orcid	0000-0002-9932-6531
person.identifier.orcid	0000-0001-8405-4249
person.identifier.rid	JTV-3288-2023
person.identifier.scopus-author-id	57214122402
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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