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The influence of pericardial fat on left ventricular diastolic function
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Advisor(s)
Abstract(s)
Abstract: Background: Heart failure is a major cause of morbidity and mortality worldwide; left
ventricular diastolic dysfunction plays a leading role in this clinical context. Diastolic dysfunction may
be predisposed by increased abdominal fat and, consequently, increased pericardial and epicardial
adiposity. This study aimed to determine whether pericardial fat (PF) and epicardial fat (EF) are
associated with left ventricular diastolic function. Methods: A total of 82 patients had their abdominal
circumference measured and underwent transthoracic echocardiography to measure the thickness
of PF and EF and assess the left ventricular diastolic function. Two groups were created based on
mean pericardial fat (PF) thickness (4.644 mm) and were related to abdominal circumference and
echocardiographic parameters. Results: Subjects in the PF High group showed a significant decrease
in septal e’ (p < 0.0001), lateral e’ (p < 0.0001), and E/A ratio (p = 0.003), as well as a significant
increase in E/e’ ratio (p < 0.0001), E wave deceleration time (p = 0.013), left atrial volume (p < 0.0001),
the left ventricle mass (p = 0.003), tricuspid regurgitant jet velocity (p < 0.0001), and the left ventricle
diameter (p = 0.014) compared to the PF Low group. Correlations were found between pericardial fat
and nine echocardiographic parameters in the study, while epicardial fat (EP) only correlated with
eight. Conclusions: Measurement of abdominal circumference, PF, and EF is an early indicator of
diastolic changes with transthoracic echocardiography being the gold standard exam.
Description
Keywords
Pericardium Echocardiography Ventricular dysfunction Heart failure Diastolic Abdominal circumference
Citation
COELHO, Patrícia [et al.] (2024) - The influence of pericardial fat on left ventricular diastolic function. Diagbnostics. Vol. 14, 702. DOI: https://doi.org/10.3390/diagnostics14070702
Publisher
MDPI