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Publication
Epidermolysis bullosa, uma sentença de morte: terapias genéticas e celulares
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Advisor(s)
Abstract(s)
Objetivo
Conhecer a fisiopatologia da doença, analisar as
principais formas terapêuticas disponíveis bem
como projetar o possível decurso da sua evolução.
Materiais e Métodos
Foi elaborada uma abordagem aos vários tipos
da doença e às terapias genéticas e celulares
existentes de forma a poder compará-las e analisálas adequadamente através de uma revisão da
literatura.
Resultados Principais
Como todo o tipo de terapias e drogas, as utilizadas
na Epidermolysis Bullosa apresentam aspetos
positivos e negativos que devem ser tidos em conta
antes da sua utilização num paciente com EB. Assim,
uma gestão das vantagens e desvantagens é crucial
para o mantimento do bem-estar do paciente.
Nenhuma das terapêuticas encontradas na revisão
da literatura se apresentam com um potencial de
cura.
Conclusão
A sensibilização da população relativamente a esta
patologia é essencial, assim como a promoção do
interesse no desenvolvimento técnico e científico
das terapias existentes e de novas terapias.
ABSTRACT Objective To know the pathophysiology of the disease, to analyse the main available therapeutic forms as well as to project the possible course of its evolution. Materials and Methods An approach to the various types of the disease and to existing genetic and cellular therapies was developed in order to be able to compare and analyze them properly through a literature review. Main results Like all types of therapies and drugs, those used in Epidermolysis Bullosa have positive and negative aspects that must be considered before their use in patients. The management of the advantages and disadvantages of this therapies is crucial for maintaining the patient’s well-being. None of the therapies found in the literature review have a healing potential. Conclusion Sensitizing the population regarding this pathology is essential, as well as promoting interest in the technical and scientific development of existing therapies and new therapies.
ABSTRACT Objective To know the pathophysiology of the disease, to analyse the main available therapeutic forms as well as to project the possible course of its evolution. Materials and Methods An approach to the various types of the disease and to existing genetic and cellular therapies was developed in order to be able to compare and analyze them properly through a literature review. Main results Like all types of therapies and drugs, those used in Epidermolysis Bullosa have positive and negative aspects that must be considered before their use in patients. The management of the advantages and disadvantages of this therapies is crucial for maintaining the patient’s well-being. None of the therapies found in the literature review have a healing potential. Conclusion Sensitizing the population regarding this pathology is essential, as well as promoting interest in the technical and scientific development of existing therapies and new therapies.
Description
Keywords
Epidermolysis bullosa Mutações Terapia genética Terapia celular Epidermolysis bullosa Mutations Gene therapy Cell therapy
Citation
LUCIANO, Bruna ; RODRIGUES, Francisco ; COELHO, Patrícia (2020) - Epidermolysis bullosa, uma sentença de morte : terapias genéticas e celulares. HIGEIA : Revista Científica da Escola Superior de Saúde Dr. Lopes Dias. ISSN 2184-5565. Ano II, vol 4, nº 2, p. 29-39.
Publisher
IPCB. ESALD